1.
Am J Transplant
; 23(2): 294-297, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: covidwho-2278883
RESUMEN
Lung transplant candidates who are highly sensitized against human leucocyte antigen present an ongoing challenge with regards to finding immunologically acceptable donors. Desensitization strategies aimed at reducing preformed donor-specific antibodies have a number of limitations. Imlifidase, an IgG-degrading enzyme derived from Streptococcus pyogenes, is a novel agent that has been used to convert positive crossmatches to negative in kidney transplant candidates, allowing transplantation to occur. We present the first case of imlifidase use for antibody depletion in a highly sensitized lung transplant candidate who went on to undergo a successful bilateral lung transplant.
Asunto(s)
Trasplante de Riñón , Trasplante de Pulmón , Humanos , Anticuerpos , Inmunosupresores , Trasplante de Riñón/efectos adversos , Donantes de Tejidos , Antígenos HLA , Trasplante de Pulmón/efectos adversos , Prueba de Histocompatibilidad , Desensibilización Inmunológica , Rechazo de Injerto/tratamiento farmacológico , Rechazo de Injerto/etiología
2.
J Cyst Fibros
; 19(3): e16-e17, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: covidwho-209731